Journal
ORGANIC LETTERS
Volume 16, Issue 23, Pages 6256-6259Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol503225s
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Funding
- Russian Science Foundation [14-13-00034]
- Russian Science Foundation [14-13-00034] Funding Source: Russian Science Foundation
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A method for nucleophilic difluoromethylation of reactive Michael acceptors, aldehydes, and azomethines is described. The reaction is performed using the readily available and air-stable reagent difluoromethylene phosphabetaine. The process involves interaction of an electrophilic substrate with in situ generated difluorinated phosphonium ylide followed by hydrolysis of the carbon-phosphorus bond under mild conditions.
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