4.8 Article

The Concise Synthesis of Spiro-Cyclopropane Compounds via the Dearomatization of Indole Derivatives

Journal

ORGANIC LETTERS
Volume 16, Issue 10, Pages 2578-2581

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol500948r

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Funding

  1. National Natural Science Foundation of China [J1210040]
  2. National Basic Research Program of China [2010CB833300]

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A concise synthesis of spiro-cyclopropane compounds from indole derivatives and sulfur ylides has been developed via a dearomatization strategy. Moreover, the spiro-cyclopropane compounds could be conveniently transformed to rearomatized indole derivatives in the presence of acids.

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