Journal
ORGANIC LETTERS
Volume 16, Issue 11, Pages 2822-2825Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol500864r
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Funding
- National Natural Science Foundation of China [81123004, 81325020, 81361120410]
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A fast and simple divergent synthesis of multisubstituted quinazolines and benzimidazoles was developed from readily available amidines, via iodine(III)-promoted oxidative C(sp(3))-C(sp(2)) and C(sp(2))-N bond formation in nonpolar and polar solvents, respectively. Further selective synthesis of quinazolines in polar solvent was realized by TEMPO-catalyzed sp(3)C-H/sp(2)C-H direct coupling of the amidine with K2S2O8 as the oxidant. No metal, base, or other additives were needed.
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