Journal
ORGANIC LETTERS
Volume 16, Issue 21, Pages 5544-5547Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol502499q
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Funding
- National Key Technologies RD Program [2011BAE06B05]
- National Natural Science Foundation of China [21172245/21172244/21372247]
- SIOC
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The first nickel-catalyzed alpha-arylation of 2-(polyfluorophenyl) pyridine with zinc enolates of esters or amides via C-F bond activation under neutral conditions is described. A variety of functional groups such as ester, amide, ether, and amine were tolerated. This method provides a simple and useful tool to synthesize fluorinated a-aryl carboxylic acids and a-aryl amides that are important intermediates for drug discovery
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