Journal
ORGANIC LETTERS
Volume 16, Issue 3, Pages 736-739Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol4034176
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Funding
- MOST [2012AA092104, 2010CB833805]
- CAS [XDA11030403, KSCX2-EW-G-12]
- NSFC [31125001, 31290233]
- Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-001, GD2012-D01-002]
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The piericidin A1 (1) gene cluster was identified from the deep-sea derived Streptomyces sp. SCSIO 03032. Our in vivo and in vitro experiments verified PieE as a 4'-hydroxylase and PieB2 as a 4'-O-methyltransferase, allowing the elucidation of the post-PKS modification steps involved in 1 biosynthesis. In addition, the shunt metabolite piericidin El (7) was identified as a novel analogue featuring a C-2/C-3 epoxy ring.
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