4.8 Article

Copper-Catalyzed Oxyazidation of Unactivated Alkenes: A Facile Synthesis of Isoxazolines Featuring an Azido Substituent

Journal

ORGANIC LETTERS
Volume 16, Issue 6, Pages 1562-1565

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol403687k

Keywords

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Funding

  1. NSFC [21272107, 21102141, 21202072]
  2. National S&T Major Project of China
  3. Fundamental Research Funds for the Central Universities [860976, 861188]

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A novel and efficient Cu(OAc)(2)-catalyzed oxyazidation of unactivated alkenes was developed. The reactions are easy to conduct, occur under mild conditions, and form azido-substituted isoxazolines in good yields.

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