Journal
ORGANIC LETTERS
Volume 16, Issue 16, Pages 4292-4295Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol502013f
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Funding
- RF [SSch 148.2014.4]
- Program of FEB RAS
- RFBR [12-04-00749-a]
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Urupocidins A and B (1 and 2), bisguanidine alkaloids with an unprecedented skeleton system, derived from polyketide precursors and containing an unusual N-alkyl-N-hydroxyguanidine moiety, have been isolated from the sponge Monanhora pulchra. The structures of 1 and 2, including absolute configuration, were established using the detailed analysis of 1D and 2D NMR, CD, and mass spectra as well as chemical transformations. Compound 1 increases nitric oxide production in murine macrophages via inducing iNOS expression.
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