Journal
ORGANIC LETTERS
Volume 16, Issue 16, Pages 4288-4291Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol502011k
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Funding
- Sun Yat-sen University
- National Science Foundation of China [81302648]
- Guangzhou Science and Technology Plan [201300000052]
- State Key Laboratory of Respiratory Disease
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3-Pinanamine is a prevalent motif in medicinal chemistry and asymmetric synthesis. In line with the pursuit of novel 3-pinanamine based anti-influenza virus A agent, the direct functionalization of 3-pinanamine was achieved by using Pd-catalyzed C(sp(3))-H activation logic. Good substrate scope and functional group tolerance were observed. The reaction represents a rare example of a direct functionalization of an aliphatic amine at the remote delta position.
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