Journal
ORGANIC LETTERS
Volume 16, Issue 24, Pages 6290-6293Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol502967x
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Funding
- GlaxoSmithKline
- EPSRC (RAS) [EP/015078]
- Engineering and Physical Sciences Research Council [EP/K038869/1] Funding Source: researchfish
- EPSRC [EP/K038869/1] Funding Source: UKRI
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The aza-Darzens reaction of substituted 2-bromoesters with chiral tert-butane- and mesitylsulfinimines provides a rapid access to a range of highly substituted aziridines in good yields and excellent levels of stereoselectivity. The synthetic potential of this protocol is further enhanced by the successful removal of the sulfinyl motif, yielding simple access to chiral NH aziridines in just three steps from commercial aldehyde precursors.
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