Journal
ORGANIC LETTERS
Volume 16, Issue 3, Pages 964-967Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol403697h
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Funding
- Royal Society for a University Research Fellowship (ADS)
- EPSRC (DSBD) [EP/J018139/1]
- Engineering and Physical Sciences Research Council [EP/J018139/1] Funding Source: researchfish
- EPSRC [EP/J018139/1] Funding Source: UKRI
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A one-pot isothiourea-mediated Michael addition/lactonization/thiol elimination cascade sequence for the formation of 4,6-disubstituted and 3,4,6-trisubstituted 2-pyrones from (phenylthio)acetic acids and alpha,beta-unsaturated trifluoro-Methyl ketones is described. The synthesis of a COX-2 inhibitor and the wide-ranging derivatization of the 2-pyrone moiety to trifluoromethyl substituted aromatics and heteroaromatics is also disclosed.
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