Journal
TISSUE ANTIGENS
Volume 85, Issue 3, Pages 155-166Publisher
WILEY-BLACKWELL
DOI: 10.1111/tan.12538
Keywords
antigen processing and presentation; disease association; human; major histocompatibility complex (MHC); tapasin; TAPBPR; TAPBPL
Categories
Funding
- Wellcome Trust [089563, 085038]
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In order to provide specificity for T cell responses against pathogens and tumours, major histocompatibility complex (MHC) class I molecules present high-affinity peptides at the cell surface to T cells. A key player for peptide loading is the MHC class I-dedicated chaperone tapasin. Recently we discovered a second MHC class I-dedicated chaperone, the tapasin-related protein TAPBPR. Here, we review the major steps in the MHC class I pathway and the TAPBPR data. We discuss the potential function of TAPBPR in the MHC class I pathway and the involvement of this previously uncharacterised protein in human health and disease.
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