4.8 Article

Synthesis of Chiral α-Diarylacetic Esters by Stereospecific 1,2-Aryl Migration Promoted by in Situ Generated Acetals from Benzoins

Journal

ORGANIC LETTERS
Volume 16, Issue 5, Pages 1278-1281

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol500292c

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Funding

  1. Department of Science and Technology (DST), India
  2. UGC UPE-II
  3. Council of Scientific and Industrial Research (CSIR), India

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A simple protocol for the synthesis of alpha-diarylacetic esters from benzoins is described. In situ generated acetal assists rapid 1,2-aryl migration in a stereospecific manner, paving the way to make enantioenriched alpha-diarylacetic esters from easily accessible enantiopure benzoins.

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