Journal
ORGANIC LETTERS
Volume 16, Issue 8, Pages 2248-2251Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol500745t
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Funding
- National Natural Science Foundation of China [21202128, 21203143]
- XJTU
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: An example of using readily available, less reactive aryl bromides as arylating reagents in the Pd(II)-catalyzed intermolecular arylation of unactivated C(sp(3))-H bonds is described. This reaction was promoted by a crucial 8-aminoquinolinyl directing group and a K2CO3 base, enabling regiospecific installation of an aryl scaffold at the beta-position of carboxamides. A mechanistic study by DFT calculations reveals a C(sp(3))-H activation-led pathway featuring the oxidative addition as the highest energy transition state.
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