Journal
ORGANIC LETTERS
Volume 16, Issue 16, Pages 4264-4267Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol5019757
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Funding
- NSFC [21172204, 41376148, 81373298, 31070045, 31125001]
- 973 Program of China [2010CB833800]
- Public Science and Technology Research Funds Projects of Ocean [201405038]
- Administration of Ocean and Fisheries of Guangdong Province [GD2012-D01-002]
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Inactivation of the O-methyltransferase gene crmM of Actinoalloteichus cyanogriseus WH1-2216-6 led to a mutant that produced three new acyclic bipyridine glycosides, cyanogrisides E-G (1-3). Further chemical analysis of the wild strain yielded 1 and another new analogue, cyanogriside H (4). Compounds 1-4 possess a skeleton consisting of a 2,2'-bipyridine and a D-quinovose or L-rhamnose sugar moiety. Cyanogriside G (3) was considered to be a key biosynthetic intermediate of the cyclic bipyridine glycosides cyanogrisides A-D. Compounds 2 and 3 showed cytotoxicities against HCTI16 and HL-60 cells, and compounds 1 and 4 were cytotoxic on K562 cells.
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