4.8 Article

Ru-Catalyzed Rearrangement of N-Methyl Isoxazolidines to N-H 1,3-Oxazinanes: A Strategy of Self-Hydride Transferring Cleavage of N-O Bonds

Journal

ORGANIC LETTERS
Volume 16, Issue 9, Pages 2498-2501

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol500869p

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Funding

  1. Fundamental Research Funds for the Central Universities [WK2060190022, WK2060190026]

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A strategy of ruthenium-catalyzed self-hydride transferring cleavage of N-O bonds was designed and utilized in a cascade 1,3-dipolar cyclization of alkenes and N-methyl nitrones followed by an N-demethylative rearrangement, furnishing synthetically useful N-H 1,3-oxazinanes.

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