Journal
ORGANIC LETTERS
Volume 16, Issue 13, Pages 3532-3535Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol501483k
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Funding
- Chinese Academy of Sciences
- National Natural Science Foundation of China [21222203, 21133011, 21372231]
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A rhodium-catalyzed sequential oxidative C-H annulation reaction between ketazines and internal alkynes has been developed via C-H and N-N bond activation with air as an external oxidant, which led to an efficient approach toward isoquinolines with high atom efficiency at rt. Utilizing the distinctive reactivity of this catalysis, both N-atoms of the azines could be efficiently incorporated to the desired isoquinolines under very robust and mild reaction conditions.
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