Journal
ORGANIC LETTERS
Volume 16, Issue 14, Pages 3672-3675Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol501454j
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Funding
- NSFC [21172062, 21273067, 21373080]
- Fundamental Research Funds for the Central Universities (Hunan University)
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An efficient synthesis of 2-hetarylquinazolin-4(3H)-ones via copper-catalyzed direct aerobic oxidative amination of sp(3)C-H bonds has been developed. This tandem oxidation-amination-cyclization transformation represents a straightforward protocol to prepare 2-hetaryl-substituted quinazolinones from easily available 2-aminobenzamides and (2-azaaryl)methanes.
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