4.8 Article

A Facile and General Approach to 3-((Trifluoromethyl)thio)-4H-chromen-4-one

Journal

ORGANIC LETTERS
Volume 16, Issue 21, Pages 5686-5689

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol502751k

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Funding

  1. Chinese Academy of Sciences
  2. National Natural Science Foundation of China [81321092]
  3. SKLDR/SIMM [SIMM1403ZZ-01]

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A facile and efficient synthetic strategy to 3-((trifluoromethyl)thio)-4H-chromen-4-one was developed. AgSCF3 and trichloroisocyanuric acid were employed here to generate active electrophilic trifluoromethylthio species in situ. This reaction could proceed under mild conditions in a short reaction time and be insensitive to air and moisture.

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