Journal
ORGANIC LETTERS
Volume 16, Issue 12, Pages 3240-3243Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol501246f
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Funding
- National Key Project for Basic Research [2010CB126100]
- National Natural Science Foundation of China [21132003, 21121002, 21372131]
- Specialized Research Fund for the Doctoral Program of Higher Education [20130031110017]
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An efficient method to prepare 1'H-spiro[indoline-3,3'-quinoline]-2',4'-diones and their trifluoromethylated products was developed via a palladium-catalyzed Sonogashira coupling/Wacker-type oxypalladation/cyclization cascade reaction. The amount of water in the reaction system played an important role in the in situ trifluoromethylation reaction, and the trifluoromethylation exhibited excellent molecular self-induced stereoselectivity.
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