Journal
ORGANIC LETTERS
Volume 16, Issue 10, Pages 2610-2613Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol5010643
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Funding
- IISER Pune
- Department of Biotechnology, Ministry of Science and Technology, India (DBT) [BT/PR6798/MED/29/636/2012]
- Council for Scientific and Industrial Research (CSIR)
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Here, we report the design, synthesis, and evaluation of arylboronate ester based diazeniumdiolates (BORO/NO), a class of nitric oxide (NO) donors activated by hydrogen peroxide (H2O2), a reactive oxygen species (ROS), to generate NO. We provide evidence for the NO donors' ability to permeate bacteria to produce NO when exposed to H2O2 supporting possible applications for BORO/NO to study molecular mechanisms of NO generation in response to elevated ROS.
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