Regioselective Allene Hydroarylation via One-Pot Allene Hydrosilylation/Pd-Catalyzed Cross-Coupling

Advances in hydroarylation have been achieved by the development of a one-pot regioselective allene hydrosilylation/Pd(0)catalyzed cross-coupling protocol. The regioselectivity is primarily governed by N-heterocyclic carbene(NHC)ligand identity in the hydrosilylation step and is preserved in the subsequent cross-coupling reaction. This methodology affords streamlined access to functionalized 1,1-disubstituted alkenes with excellent regiocontrol.