4.8 Article

Synthesis of 2-Vinylbenzofurans via the Copper-Catalyzed Multicomponent Reactions Involving an Oxa-Michael/Arylation/Vinylation Cascade

Journal

ORGANIC LETTERS
Volume 16, Issue 19, Pages 5160-5163

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol502506g

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Funding

  1. NSFC of China [21102059, 21202064, 21202144]
  2. Department of Education of Jiangxi Province [GJJ13245]

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2-vinylbenzofurans have been synthesized via the copper catalyzed. one-pot, three component reactions of o-iodophenols in situ generated allenes, and dichloromethane Cascade transformation of oxa-Michael addition C-arylation, and sp(3)C-H/sp(3)C-Cl conversion-based vinylation has been involved in realizing the construction of this 2-vinylbenzofuran framework.

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