Journal
ORGANIC LETTERS
Volume 16, Issue 12, Pages 3200-3203Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol501180q
Keywords
-
Categories
Funding
- NSERC Canada
Ask authors/readers for more resources
A new, catalytic, and general methodology for the synthesis of biaryls and heterobiaryls by the cross coupling of anthranilamide derivatives (o-NMe2 benzamides) with aryl boroneopentylates is described. The reaction proceeds under catalytic RuH2(CO)(PPh3)(3) conditions driven by the activation of the unreactive C-N bond by amide directing group (DG)-Ru catalyst chelation. High regioselectivity, orthogonality with the Suzuki-Miyaura reaction, operational simplicity, and convenient scale-up are features of these reactions which may lend themselves to industrial applications.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available