Journal
ORGANIC LETTERS
Volume 16, Issue 12, Pages 3256-3259Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol501271v
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Funding
- Nagase Science Technology Foundation
- Astellas Foundation for Research on Metabolic Disorders
- CREST program from Japan Science and Technology Agency
- Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan
- Grants-in-Aid for Scientific Research [25560399, 26303005, 25108705] Funding Source: KAKEN
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Lipodiscamides A-C, three new lipodepsipeptides, were characterized from the marine sponge Discodermia kiiensis. These structurally rare cyclic lipodepsipeptides were found to possess an unprecedented dilactone macrocycle and, thus, represent a new family of lipopeptides. They are the only lipopeptides bearing 4S-hydroxy-trans-2-enoate, and non-canonical amino acids, L-3-ureidoalanine (Uda), E-dehydronorvaline (Denor), and D-citrulline (Cit). MTT assays against P388 and HeLa cells revealed the moderate cytotoxicity of all three compounds.
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