4.8 Article

Cobalt-Catalyzed Hydroarylative Cyclization of 1,6-Enynes with Aromatic Ketones and Esters via C-H Activation

Journal

ORGANIC LETTERS
Volume 16, Issue 16, Pages 4208-4211

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol501904e

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Funding

  1. National Science Council of the Republic of China [NSC-102-2628-M-007-005]

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A highly chemo- and stereoselective cobalt-catalyzed hydroarylative cyclization of 1,6-enynes with aromatic ketones and esters to synthesize functionalized pyrrolidines and dihydrofurans is described. A mechanism involving cobaltacycle triggered C-H activation of aromatic ketones and esters was proposed.

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