Journal
ORGANIC LETTERS
Volume 16, Issue 3, Pages 928-931Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol403657r
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- Korea Institute of Ocean Science and Technology [PE99121]
- Ministry of Oceans and Fisheries, Korea [PM57420]
- Korea Institute of Marine Science & Technology Promotion (KIMST) [PE99121] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Gageotetrins A-C (1-3), a unique class of linear lipopeptides, consisting of di- and tetrapeptides and a new fatty acid were isolated from a Marine Bacillus subtilis. The structures of 1-3 were assigned by spectroscopic data and their absolute stereochemistries were ascertained by chemical derivatization. Compounds 1-3 displayed good antimicrobial activities with MIC values of 0.01-0.06 mu M. However, these compounds failed to register any cytotoxicity (GI(50) > 30 mu g/ml) against human cancer cell lines.
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