Journal
ORGANIC LETTERS
Volume 16, Issue 18, Pages 4834-4837Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol502329k
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Funding
- Natural Science Foundation of China [31330009]
- Ministry of Science and Technology of China [2010CB833802, 2013AA092901]
- Hungarian National Research Foundation [OTKA K105871]
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A new 3H-oxepine-containing alkaloid, varioxepine A (1), characterized by a structurally unprecedented condensed 3,6,8-trioxabicyclo[3.2.1]octane motif, was isolated from the marine algal-derived endophytic fungus Paecilomyces variotii. Due to the low proton/carbon ratio, the unambiguous assignment of the planar structure and relative configuration was precluded by NMR experiments and solved by single crystal X-ray analysis. The absolute configuration was established by DFT conformational analysis and TDDFT-ECD calculations. Compound 1 inhibited plant pathogenic fungus Fusarium graminearum.
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