Journal
ORGANIC LETTERS
Volume 16, Issue 2, Pages 640-643Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol403714g
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Funding
- National Institutes of Health (NIH) [DP2 GM105434, GM095450]
- Searle Scholars Program
- Harvard University
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Lomaiviticin biosynthesis is thought to utilize a propionyl starter unit for a type II polyketide synthase (PKS). Discovery of the lomaiviticin (lom) biosynthetic gene cluster suggested an unusual method for starter unit generation involving a bifunctional acyltransferase/decarboxylase (AT/DC) thus far observed only in type I PKS pathways. In vitro biochemical characterization of AT/DC Lom62 confirmed its ability to generate a propionyl-acyl carrier protein (ACP), revealing a new role for this enzymatic activity within natural product biosynthesis.
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