Journal
ORGANIC LETTERS
Volume 16, Issue 13, Pages 3544-3547Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol501496n
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Funding
- University of Hong Kong
- University Development Fund
- Hong Kong Research Grants Council under General Research Fund Scheme [HKU 706410]
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A HKOCl-2 series of new fluorescent probes for hypochlorous acid (HOCl) detection in live cells is reported. The probes exhibit excellent selectivity, sensitivity, and chemostability toward HOCl. In particular, HKOCl-2b rapidly and selectively detects endogenous HOCl in both human and mouse macrophages. These probes could therefore serve as promising discovery tools to help elucidate biological functions of HOCl.
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