4.8 Article

HKOCl-2 Series of Green BODIPY-Based Fluorescent Probes for Hypochlorous Acid Detection and Imaging in Live Cells

Journal

ORGANIC LETTERS
Volume 16, Issue 13, Pages 3544-3547

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol501496n

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Funding

  1. University of Hong Kong
  2. University Development Fund
  3. Hong Kong Research Grants Council under General Research Fund Scheme [HKU 706410]

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A HKOCl-2 series of new fluorescent probes for hypochlorous acid (HOCl) detection in live cells is reported. The probes exhibit excellent selectivity, sensitivity, and chemostability toward HOCl. In particular, HKOCl-2b rapidly and selectively detects endogenous HOCl in both human and mouse macrophages. These probes could therefore serve as promising discovery tools to help elucidate biological functions of HOCl.

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