Journal
ORGANIC LETTERS
Volume 16, Issue 15, Pages 3974-3977Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol501802w
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Funding
- National Research Foundation of Korea (NRF) - Korea government (MSIP) [2008-0061983]
- National Research Foundation of Korea [2008-0061983] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Given the importance of homogeneous catalysts recycling in organic chemistry, we have developed a unique microfluidic loop system for automated continuous recirculation of a soluble polymer supported metal catalyst for novel isocyanide cross-coupling reactions under thermomorphic multicomponent solvent (TMS) conditions. Our system provides an innovative approach for the chemical library synthesis of quinazolinone derivatives as well as an important intermediate of Merck's LTD4 antagonist Singulair with efficient continuous homogeneous catalyst recycling.
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