Journal
ORGANIC LETTERS
Volume 16, Issue 17, Pages 4520-4523Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol5020637
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Funding
- National Natural Science Foundation of China [21173089, 21373093]
- fundamental research funds for the central universities in China [2014ZZGH019]
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A concise method to synthesize 1,2,3,4-tetrahydropyridines is described that involves the use of 2-alkoxy-3,4-dihydropyran as a modular precursor to react with aniline and a nucleophile. In this method, the heteroatom of the dihydropyran ring was replaced by nitrogen of aniline while the nucleophile attached to its adjacent position. Various druglike polyheterocycles were prepared with this method by using NH2-containing 1,5- or 1,4-bisnucleophiles.
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