Journal
ORGANIC LETTERS
Volume 16, Issue 7, Pages 1916-1919Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol5004324
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Funding
- Ministry of Education, Science, Sports, and Culture of Japan [25350959]
- Platform for Drug Discovery, Informatics, and Structural Life Science from the Ministry of Education, Culture, Sports, Science, and Technology, Japan
- Suntory Institute for Bioorganic Research
- Astellas Foundation for Research on Metabolic Disorders
- Grants-in-Aid for Scientific Research [25350959] Funding Source: KAKEN
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Through the combination of natural products chemistry and diversity-oriented synthesis, a new approach, diversity-enhanced extracts, for increasing the diversity of natural product-like compounds is proposed. They are prepared from chemical reactions that remodel molecular scaffolds directly on extracts of natural resources. This method was applied to terpenes extracted from Curcuma zedoaria. Epoxidation and subsequent ring-opening reactions of epoxides were used to modify molecular skeletons. As a result, seven sesquiterpene-like compounds with some containing new molecular skeletons were obtained.
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