4.8 Article

Lewis Acid/Bronsted Acid Mediated Benz-Annulation of Thiophenes and Electron-Rich Arenes

Journal

ORGANIC LETTERS
Volume 16, Issue 10, Pages 2720-2723

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol501006t

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Funding

  1. DST New Delhi
  2. UGC

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A facile preparation of benz-annulated heterocycles were achieved at rt involving a Lewis acid/Bronsted acid mediated annulation of heterocycles using 2,5-dimethoxytetrahydrofuran as a four-carbon synthon. The benz-/naphth-annulation was found to be successful with electron-rich arenes as well.

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