Journal
ORGANIC LETTERS
Volume 16, Issue 21, Pages 5728-5731Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol5027975
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Funding
- National Natural Science Foundation of China [21472147, 21272183]
- Fund of the Rising Stars of Shanxi Province [2012KJXX26]
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A p-TsOH-mediated 1,3-dipolar cycloaddition of nitroolefins and sodium azide for the synthesis of 4-aryl-NH-1,2,3-triazoles has been developed. p-TsOH was discovered as a vital additive in this type of 1,3-dipolar cycloaddition. This novel cycloaddition reaction is a good method for the rapid synthesis of valuable 4-aryl-NH-1,2,3-triazoles in high yields.
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