4.8 Article

p-Toluenesulfonic Acid Mediated 1,3-Dipolar Cycloaddition of Nitroolefins with NaN3 for Synthesis of 4-Aryl-NH-1,2,3-triazoles

Journal

ORGANIC LETTERS
Volume 16, Issue 21, Pages 5728-5731

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol5027975

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Funding

  1. National Natural Science Foundation of China [21472147, 21272183]
  2. Fund of the Rising Stars of Shanxi Province [2012KJXX26]

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A p-TsOH-mediated 1,3-dipolar cycloaddition of nitroolefins and sodium azide for the synthesis of 4-aryl-NH-1,2,3-triazoles has been developed. p-TsOH was discovered as a vital additive in this type of 1,3-dipolar cycloaddition. This novel cycloaddition reaction is a good method for the rapid synthesis of valuable 4-aryl-NH-1,2,3-triazoles in high yields.

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