Journal
ORGANIC LETTERS
Volume 16, Issue 10, Pages 2716-2719Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol501002a
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A novel synthesis of vernakalant is described. Using inexpensive and readily available reagents, the key transformations involve (1) an efficient zinc-amine-promoted etherification, (2) a highly stereoselective enzyme-catalyzed dynamic asymmetric transamination to set up the two contiguous chiral centers in the cyclohexane ring, and (3) a pyrrolidine ring formation via alkyl-B(OH)(2)-catalyzed amidation and subsequent imide reduction.
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