4.8 Article

A Chemoselective Route to β-Enannino Esters and Thioesters

Journal

ORGANIC LETTERS
Volume 16, Issue 8, Pages 2108-2110

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol5005643

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Funding

  1. National Institutes of Health [GM087981]
  2. Robert A. Welch Foundation [A-1121]

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Conditions were developed for syntheses of beta-enamino esters, thioesters, and amides. These reactions involve hydroxybenzotriazole derivatives in buffered media. Illustrative syntheses of some heterocyclic systems are given, including some related to protein protein interface mimics.

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