Journal
ORGANIC LETTERS
Volume 15, Issue 9, Pages 2302-2305Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol400888r
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Funding
- NIH NIGMS [GM073836]
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A Pd-catalyzed method for ligand-directed C-H alkylation with organoboron reagents is described. The combination of potassium organo-trifluoroborates, MnF3, and a Pd-II catalyst effects pyridine and amide-directed C-H alkylation. These reactions proceed under mild conditions (25-40 degrees C in weakly acidic media), are effective for installing methyl and 1 degrees alkyl groups, and do not require promoters such as benzoquinone.
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