4.8 Article

Novel Syntheses of Fluorenones via Nitrile-Directed Palladium-Catalyzed C-H and Dual C-H Bond Activation

Journal

ORGANIC LETTERS
Volume 15, Issue 11, Pages 2742-2745

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol401063w

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Funding

  1. National Science Council of the Republic of China [NSC-101-2113-M-032-004-MY2]

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Novel procedures for the [Pd]/[Ag]/TFA system catalyzed cascade reactions of nitrile directed remote C-H and dual C-H bond activation with insertion of nitrile were developed, which afforded variously polysubstituted fluorenones in moderate to good yields with tolerance of a wide variety of substrates.

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