Journal
ORGANIC LETTERS
Volume 15, Issue 13, Pages 3354-3357Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol401404y
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Funding
- Hundred Talent Program of CAS
- State Key Lab of Fine Chemicals [KF1201]
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An unprecedented protocol for the copper-mediated direct cyanation of aryl C-H by employing 2,2'-azobisisobutyronitrwile (AIBN) as a free radical CN source is presented. The protocol not only provides a more efficient pathway for the synthesis of aryl nitriles in terms of the yields and the loading amount of copper salts but also, more importantly, represents a novel strategy for aryl C-H cyanation via a CN free-radical mechanism as compared to the CN anion-participating protocols often reported.
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