4.8 Article

Highly Selective β-Hydride Elimination in Pd-Catalyzed Decarboxylative Heck-Type Reaction

Journal

ORGANIC LETTERS
Volume 15, Issue 10, Pages 2330-2333

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol400818v

Keywords

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Funding

  1. National Natural Science Foundation of China [21172076, 20932002]
  2. National Basic Research Program of China (973 Program) [2011CB808600]
  3. Changjiang Scholars and Innovation Team Project of Ministry of Education
  4. Guangdong Natural Science Foundation [10351064101000000]
  5. Fundamental Research Funds for the Central Universities [2012ZP0003]

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A variety of beta-aryl ketones and aldehydes were facilely synthesized via a Pd(II)/Ag2CO3-mediated decarboxylative Heck type reaction between readily available benzoic acid derivatives and allylic alcohols under mild conditions. The control experiments indicated that this transformation may proceed via a hydrogen migration process.

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