4.8 Article

Hypochlorous Acid Turn-on Fluorescent Probe Based on Oxidation of Diphenyl Selenide

Journal

ORGANIC LETTERS
Volume 15, Issue 4, Pages 878-881

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol400011u

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Funding

  1. National Science Council (ROC)
  2. National Chiao Tung University

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A BODIPY-based fluorescent probe, HCSe, has been successfully developed for the rapid detection of hypochlorous acid based on the specific HOCl-promoted oxidation of diphenyl selenide in response to the amount of HOCl. Confocal fluorescence microscopy imaging using RAW264.7 cells showed that the new probe HCSe could be used as an effective fluorescent probe for detecting HOCl in living cells.

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