4.8 Article

Copper-Catalyzed C-O Bond Formation: An Efficient One-Pot Highly Regioselective Synthesis of Furans from (2-Furyl)Carbene Complexes

Journal

ORGANIC LETTERS
Volume 15, Issue 5, Pages 1080-1083

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol400080e

Keywords

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Funding

  1. Foundation for National Natural Science
  2. Foundation of China [20932002, 21172076]
  3. National Basic Research Program of China (973 Program) [2011CB808600]
  4. Ministry of Education of China [20090172110014]
  5. Guangdong Natural Science Foundation [10351064101000000]
  6. Distinguished Young Talentsin Higher Education of Guangdong, China [LYM11083]

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A convenient one-pot Cu(I)-catalyzed strategy for regioselective synthesis of trisubstituted furan derivatives has been developed via (2-furyl) carbene complexes. This process has opened a new synthetic route to a variety of alpha-carbonyl furans using air as the oxidant affording furans in good yields.

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