Journal
ORGANIC LETTERS
Volume 15, Issue 20, Pages 5194-5197Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol402262c
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Funding
- State Key Laboratory of Applied Organic Chemistry
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An efficient method for the Pd-catalyzed regioselective C-2 arylation of quinolines is presented. Reactions of various substituted quinolines and unactivated arenes have been conducted under mild conditions. The result shows good product yields of 2-arylquinolines, which are highly useful building blocks for the synthesis of bioactive alkaloid natural products and drug molecules.
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