4.8 Article

Cobalt-Catalyzed Acceptorless Alcohol Dehydrogenation: Synthesis of Imines from Alcohols and Amines

Journal

ORGANIC LETTERS
Volume 15, Issue 3, Pages 650-653

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol303479f

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Funding

  1. Los Alamos National Laboratory LDRD Early Career Award [2011-0537ER]
  2. Post-Doctoral Fellowship

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A cobalt catalyst has been developed for the acceptorless dehydrogenation of alcohols and applied to synthesize Imines from alcohols and amines. Deuterium labeling studies suggest that the reaction proceeds by an initial reversible alcohol dehydrogenation step involving a cobalt hydride intermediate.

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