Journal
ORGANIC LETTERS
Volume 15, Issue 23, Pages 5967-5969Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol402810f
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Funding
- National Natural Science Foundation of China [81072516, 81273356]
- Project of Science Technology Department of Zhejiang Province [2012C33065]
- Project of Education Department of Zhejiang Province [Y201223193]
- Program for Zhejiang Leading Team of ST Innovation
- Diabetes Research Group, USA
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A simple, multicomponent, and straightforward reaction of vinyl azide, aldehyde, and tosylhydrazine affords the construction of 3,4,5-trisubstituted 1H-pyrazoles regioselectively in the presence of base with moderate to excellent yields. A range of functionality could be tolerated in this methodology, and a possible mechanism is proposed.
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