Journal
ORGANIC LETTERS
Volume 15, Issue 9, Pages 2160-2163Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol4006757
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- Funding Program for Next Generation World-Leading Researchers (JSPS)
- JSPS
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A direct conversion of C(sp(3))-H bonds to C(sp(3))-F bonds has been developed. In this process, a catalytic N-oxyl radical generated from N,N-dihydroxypyromellitimide abstracts hydrogen from the C(sp(3))-H bond and Selectfluor acts to trap the resulting carbon radical to form the C(sp(3))-F bond. This simple metal-free protocol enables the chemoselective introduction of a fluorine atom into various aromatic and aliphatic compounds and serves as a powerful tool for the efficient synthesis of fluorinated molecules.
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