Journal
ORGANIC LETTERS
Volume 15, Issue 16, Pages 4250-4253Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol4020333
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Funding
- EPSRC
- European Research Council (ERC) [246785]
- Universita degli studi di Siena
- University of Bristol
- EPSRC [EP/E052185/1, EP/I038071/1, EP/K03927X/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I038071/1, EP/K03927X/1, EP/E052185/1] Funding Source: researchfish
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3-Methyl vinyl aziridine undergoes a mild MgI2-promoted S(N)2' ring opening and concomitant cyclization with fumarate Michael acceptors to give trisubstituted pyrrolidines. The process is efficient and highly diastereoselective. This methodology has been applied to a concise asymmetric synthesis of (+)-allo-kainic acid.
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