4.8 Article

Rhodium(III)-Catalyzed Intermolecular N-Chelator-Directed Aromatic C-H Amidation with Amides

Journal

ORGANIC LETTERS
Volume 15, Issue 19, Pages 5106-5109

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/ol4024776

Keywords

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Funding

  1. 973 Program [2011CB932404, 2011CBA00501]
  2. NSFC [20925102, 21202164]
  3. National Key Technology R D Program [2012 BAE 06B08]

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Rh(III)-catalyzed intermolecular direct aromatic C-H bond amidation with amides has been accomplished under mild reaction conditions. This protocol is applicable to a broad range of N-chelator-containing arenes amidated with aromatic and aliphatic sulfonamides. A possible mechanism is proposed according to the experimental results.

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