Journal
ORGANIC LETTERS
Volume 15, Issue 14, Pages 3582-3585Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol401421r
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Funding
- CRI program from the National Research Foundation (NRF) of Korea
- GRL program from the National Research Foundation (NRF) of Korea [2010-00353]
- WCU program from the National Research Foundation (NRF) of Korea [R31-2008-000-100 10-0]
- National Research Foundation of Korea [2010-00353] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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We have developed a series of molecular probes for the fluorescent detection of singlet dioxygen (O-1(2)). The probes, based on asymmetrically substituted 1,3-diarylisobenzofurans, undergo the [2 + 4] cycloaddition reaction with O-1(2), producing ratiometric fluorescent responses. Two-photon fluorescence microscope experiments demonstrated the biological utility of the probes for the visualization of endogenous O-1(2) in macrophage cells.
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