Journal
ORGANIC LETTERS
Volume 16, Issue 1, Pages 54-57Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol403007j
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Funding
- Loker Hydrocarbon Research Institute
- National Science Foundation [1048807]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1048807] Funding Source: National Science Foundation
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Direct N-difluoromethylation of imidazoles and benzimidazoles has been achieved using TMS-CF3 (the Ruppert-Prakash reagent) under neutral conditions. Difluoromethylated products were obtained in good-to-excellent yields. Inexpensive, commercially available starting materials, neutral conditions, and shorter reaction times are advantages of this methodology. Reactions are accessible through conventional as well as microwave irradiation conditions.
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